Historical records hint at the use of magic mushrooms dating as far back as 9000 B.C. among North African indigenous cultures, with depictions found in ancient rock paintings. Similarly, in Central American ruins belonging to Mayan and Aztec civilizations, artifacts resembling mushrooms have been discovered, suggesting their potential ceremonial use. The Aztecs notably referred to a substance as teonanácatl, translating to "flesh of the gods," which many believe to be magic mushrooms. Alongside peyote and morning glory seeds, these mushrooms were utilized to induce trance-like states, evoke visions, and facilitate communication with divine entities. Accounts from Spanish Catholic missionaries in the 16th century also document the use of such psychotropic substances upon their arrival in the New World.

However, the assertion of a lengthy and sacred history for magic mushrooms remains contentious. Skeptics argue that the evidence presented, including ancient artworks and texts, may be subject to interpretation bias. Despite this debate, contemporary indigenous tribes in Central America, such as the Mazatec, Mixtec, Nauhua, and Zapatec, continue to engage in the ritualistic use of magic mushrooms.

The Western consumption of magic mushrooms gained traction in the late 1950s. Renowned mycologist R. Gordon Wasson encountered these mushrooms during a research expedition in Mexico in 1955, where he participated ina ceremony led by Maria Sabina, a renowned Mazatec shaman and healer, in the village of Huautla de Jiménez, located in the rugged mountains of the Sierra Mazateca region in the state of Oaxaca.. Wasson's subsequent article, published in Life magazine in 1957 under the title "Seeking the Magic Mushroom," introduced the term to the public. Collaborating with Albert Hofmann, the discoverer of LSD, Wasson's colleague Roger Heim isolated psilocybin and psilocin from the mushrooms, paving the way for further study.

Timothy Leary, a prominent advocate for psychedelic substances, was inspired by Wasson's work and began experimenting with magic mushrooms at Harvard University. This association with academia soon intertwined with the burgeoning hippie movement of the 1960s, becoming emblematic of countercultural exploration.

In contemporary times, magic mushrooms are undergoing a reevaluation in popular culture. The practice of "microdosing" psilocybin, involving the consumption of small doses to enhance mood and creativity without inducing full psychedelic experiences, has gained popularity. Scientific research into the therapeutic potential of these substances has also expanded significantly. Despite a 1970s ban on psilocybin, recent years have seen a resurgence in medical research. FDA approval has been granted to investigate the efficacy of mushrooms in treating depression. Additionally, institutions such as Johns Hopkins University have established dedicated centers to explore the potential applications of psilocybin in addressing various mental health conditions and dependencies.

Researchers worldwide are delving into the intricate interactions between magic mushrooms and the human brain and body, aiming to unlock their therapeutic potential. Their endeavors may lead to groundbreaking insights and novel treatments for a range of ailments, offering hope for those seeking alternative approaches to healing and well-being.